A Rare Case of Seizures Secondary to Proton Pump Inhibitors-Induced Hypomagnesemia
Author(s):
Vittoria Gammaldi, Carolina Bologna, Tiziana Ciarambino, Antonietta De Sena, Maria Gabriella Coppola, Marina Lugara, Benedetta Tartaglia, Carmine Pio Petrosino, Claudio de Luca, Fabio Granato Corigliano, Mariavittoria Guerra, Gabriella Oliva, Pasquale Madonna and Paolo Tirelli
Hypomagnesemia is a side effect in patients in treatment with proton pump inhibitors (PPI) for more than one year. It can cause arrhythmias, tetany, seizure, and it can be a life-threatening condition. We describe the case of a 78-year-old man with history of relapsing tonic clonic seizures (TCZ), remote stroke, who presented to emergency department for another episode of TCZ. At blood tests, he had severe hypomagnesemia (0.39 mmol/L). After excluding other causes for hypomagnesaemia, chronic use of PPIs was considered a plausible cause. Therefore, substitutive therapy was initiated to restore blood levels of magnesium, and PPIs were discontinued.