Clinical study on the relationship between neopterin and polycystic ovary syndrome
Author(s):
Junjie Zhou, Mo Yang, Yanan Wang, Han Wu, Mengchen Liu, Wenjuan Zhang
Objectives: Polycystic ovary syndrome (PCOS) is a reproductive endocrine and metabolic disorder. To offer new research direction for PCOS, including its pathogenesis and treatment, this research explores the relationship between neopterin (NPT) and polycystic ovary syndrome.
Material and Methods: This is a prospective study. 80 cases with PCOS were selected in the reproductive medicine clinics of the Second Affiliated Hospital of Shandong First Medical University as PCOS group from January 2020 to December 2021. 80 cases with normal pregnancy plan were treated as non-PCOS group, whose menstruation is from 25 days to 35 days. We divided the two groups into two subgroups separately according to their body mass index (BMI): the obese one with BMI≥25kg/m2 and non-obese one with BMI<25kg/m2.
Results: The expression levels of triglycerides (TG), total cholesterol (TC), fasting insulin (FINS), C-reactive protein (CRP), neutrophil (N), NPT and interleukin-6 (IL-6) in PCOS group were higher than non-PCOS group. CRP, NPT and IL-6 in the obese group were increased than the non-obese group in the pairwise comparison of its subgroups whether in PCOS group or non-PCOS group. In the analysis of linear correlation, NPT was positively correlated with TG, TC, WBC, N, CRP, FINS, IL-6 and TNF-α (P<0.01). Multivariate Stepwise regression analysis found that FINS and IL-6 was the two most important factors.
Conclusion: The expression of NPT in PCOS patients was higher than non-PCOS. NPT maybe play a significant role in the development of PCOS.