Combined with Targeted Therapy Intensively Modulated Radiotherapy for Inoperable Giant Cell Sacral Tumor��?Three - Year Follow-up of a Rare Borderline Tumor with Literature Review
Author(s):
Lena Marinova*, Radoslav Georgiev and Kremena Petrova
Giant cell bone tumors are rare benign, locally aggressive neoplasms, involving predominantly young patients. In a 26-year-old patient with inoperable sacral giant cell tumor, definitive intensive-modulated radiotherapy (IMRT) up to total dose 64Gy with daily dose 2 Gy was performed. After 3 years of diagnosis and complex treatment (radiotherapy and targeted therapy) the patient is asymptomatic, with achieved local tumor control, without distant metastases and without dynamics in terms of bone recalcification. Radiotherapy is an alternative to surgery for axial bone localizations with a high risk of unacceptable postoperative deformities.