Extremely rare primary undifferentiated pleomorphic thyroid sarcoma-Clinical case with a literary review
Author(s):
Marinova L, Vasileva V, Gabrovski I, Petrov V, Kahchiev N
Anaplastic thyroid carcinoma (ATC) known as undifferentiated and dedifferentiated carcinoma, is a rare, highly aggressive neoplasm. We present an extremely fast growing undifferentiated pleomorphic sarcoma originating in the thyroid gland in an 80-year-old woman. Through this clinical case, we show the importance of the pathohistological characteristic and immunohistochemical analysis for diagnosis of these extremely malignant neoplasms. Due to the radiation- and chemoresistance of this malignant undifferentiated soft tissue neoplasm, early diagnosis for a small tumor volume without distant hematogenous metastases is required to perform maximum radical surgery. Locally advanced sarcomas with lung metastases are subject to symptomatic and palliative treatment and the prognosis is very unfavorable.