Medical & Clinical Research

Author(s): Mohammed Al Abadie, Zinah Sharara

Vitiligo is a prevalent autoimmune depigmenting skin disorder, affecting 0.5–2% of the global population. While often believed a cosmetic issue, vitiligo can have profound psychological impact on the patients. The disease is marked by the loss of functional melanocytes, driven by complex interactions between the innate and adaptive immune systems, leading to various proposed mechanisms of melanocyte destruction. This paper provides a narrative overview of vitiligo treatments, encompassing established therapies, unconventional approaches, and recently licensed molecular-targeted treatments. Additionally, highlighting emerging therapeutic strategies currently under investigation, aiming to provide a broad perspective on the management and potential future directions in vitiligo care.