Medical & Clinical Research

Author(s): Miranda Nava Gabriel and Garc�­a Garc�­a Luis Gilberto

Introduction: Primary lateral sclerosis is a rare disease that involves the upper motor neuron, producing a bulbospinal spasticity. The course of the disease is insidious and progressive, usually beginning with the lower extremities, and subsequently becoming a tetrapyramidal syndrome. Being a rare disease, the diagnosis in most cases is exclusion, having to study the patient extensively, in a clinical manner, including a thorough clinical history, laboratory and with relevant cabinet studies.

Clinical Case: This is a male patient who started his clinical picture about a year ago with weakness in the left pelvic limb, later accompanied by pain and paraesthesia, manifesting the same symptoms later in the contralateral leg and upper left limb. Currently, hypoesthesia of the index and middle toes of the right foot is added, moderate tremor in the left arm, with overlapping of the middle finger over the ring of said hand. He has an inability to lift light objects for short periods of time, as well as fatigue in short periods of time when performing daily activities, which greatly limits his daily life.

Conclusions: Motor neuron diseases are divided into two groups, and in the case studied, the upper motor neuron is exclusively affected. Being a rare disease, with a low incidence, multiple differential diagnoses will be considered before concluding this, considering a diagnosis of exclusion. The natural history of the disease will always have a bleak outcome, with a poor prognosis for life and function, despite the measures taken to modify its course.